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You are here:Home » Growth Factors, Cytokines » Growth Factors-Defensin » BD1, Control Peptide (beta Defensin-1)

BD1, Control Peptide (beta Defensin-1)

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Specifications

Control Peptide for B0900-09 (antiserum)
Catalog #B0900-09A
Mouse and rat MBD-1 is synthesized from 69 aa precursor (mature peptide 33-69 aa). A 16aa Peptide sequence near the N-terminus of mature MBD-1.
Antimicrobial peptides are a common mechanism of host defense utilized by a variety of species, from insects to humans. Defensins are a large family of broad-spectrum antimicrobial peptides, identified originally in leukocytes of rabbits and humans. Defensins, cationic/polar peptides (30-35 aa; 3-4kD), are distinguished by a conserved tri-disulfides and a largely b-Sheet structure. Defensins, expressed at the cell surface, have been hypothesized to function as a biochemical barrier against microbial infection by inhibiting colonization of the epithelium by wide range of pathogenic microorganisms. In leukocytes, these peptides are stored in cytoplasmic granules and are released into phagolysosomes where they contribute to the killing of engulfed microorganisms.
The genes encoding human a and ß -defensins are clustered in a contiguous segment of chromosome 8p23. Defensins are classified into two families designated a-and ß-based on distinctive, although similar, tri-disulfide linkages in the peptides. b-defensins are slightly larger and differ in the position and arrangement of 3 disulfides. In humans, six a -defensin (cryptidins), HD 1-6 (HD1-4 are also known as HNP1-4 for Human Neutrophil Peptides), and two ß -defensins, HBD-1 and HBD-2, have been identified to date. Rat (RBD-1 and RBD-2) and mouse (MBD1-4) homologues of the human beta-defensin have also been identified.a-defensins are encoded by genes designated DEFA1-6, whereas human b-defensins are encoded by the DEFB1 and DEFb2 genes.
ApplicationsSuitable for use in ELISA, Antibody Blocking. Not suitable for use in Western Blot. Other applications not tested.
Recommended DilutionELISA: 1ug/ml per well
Antibody Blocking: 5-10ug
Optimal dilutions to be determined by the researcher.
Storage and StabilityFor long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceMouse, synthetic peptide
PurityHighly purified
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
SpecificitySpecies sequence homology: Rat 87% . No significant homology exists with human beta-defensin 1 or other defensins
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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