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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -BD3 (beta Defensin-3, CTIP1) (HRP)

Anti -BD3 (beta Defensin-3, CTIP1) (HRP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B
A novel, nonhemolytic antimicrobial peptide (human beta-defensin-3, hBD-3) was isolated from human lesional psoriatic scales and clones from keratinocytes. hBD-3 demonstrated a salt-insensitive broad spectrum of potent antimicrobial activity against many potentially pathogenic microbes including multiresistant S. aureus and vancomyosin-resistant Entoerococcus faecium. Keratinocytes and airway epithelial cells are cellular sources of hBD-3. Tumor necrosis factor alpha and contact with bacteria were found to induce hBD-3 mRNA expression. hBD-3, therefore, might be important in the innate epithelial defense of infections by various microorganisms seen in skin and lung, such as cystic fibrosis.
Catalog #B0902-02A1
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000 (ECL)
Immunofluorescence: 1:100-1:200 (Suggested; not tested)
Optimal dilutions to be determined by the researcher.
Storage and StabilityStore at 4°C. Do Not Freeze. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2. No preservative and no stabilizing protein added. Conjugated to horseradish peroxidase (HRP).
PurityPurified IgG
ImmunogenSynthetic peptide corresponding to residues 23-33 [GIINTLQKYYC] of hBD-3 protein. MW of Antigen: 5kD
SpecificityRecognizes residues 23-33 (GIINTLQKYYC) of the 5 kD hBD-3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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