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You are here:Home » Molecular Biology » MB-Peptides » BD3 full length, Mouse Control Peptide (beta-Defensin 3)

BD3 full length, Mouse Control Peptide (beta-Defensin 3)

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Specifications

Control Peptide for (affinity purified) and (antiserum).
Synthetic peptide, 63 aa precursor (mature peptide 24-63 aa).
Catalog #B0902E
Antimicrobial peptides are a common mechanism of host defense utilized by a variety of species, from insects to humans. Defensins are a large family of broad-spectrum antimicrobial peptides, identified originally in leukocytes of rabbits and humans. Defensins, cationic/polar peptides (30-35 aa; 3-4kD), are distinguished by a conserved tri-disulfides and a largely b-Sheet structure. Defensins, expressed at the cell surface, have been hypothesized to function as a biochemical barrier against microbial infection by inhibiting colonization of the epithelium by wide range of pathogenic microorganisms.
The genes encoding human and -defensins are clustered in a contiguous segment of chromosome 8p23. Defensins are classified into two families designated – and -based on distinctive, although similar, tri-disulfide linkages in the peptides. b-defensins are slightly larger and differ in the position and arrangement of 3 disulfides. In humans, six –defensin (cryptidins), HD 1-6 (HD1-4 are also known as HNP1-4 for Human Neutrophil Peptides), and two -defensins, HBD-1 and HBD-2, have been identified to date. Rat (RBD-1 and RBD-2) and mouse (MBD1-4) homologues of the human beta-defensin have also been identified. a-defensins are encoded by genes designated DEFA1-6, whereas human b-defensins are encoded by the DEFB1 and DEFb2 genes
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
PuritySupplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
ConcentrationAs reported
FormPurified
SpecificityThe MBD-3 sequence is ~ 50% conserved bovine and human beta defensin-3. Biological activity has not been established.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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