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You are here:Home » Antibodies » Abs to Autophagy » Anti -Beclin-1 (Coiled-coil Myosin-like Bcl-2-Interacting Protein, ATG6, BECN1, GT197, VPS30)

Anti -Beclin-1 (Coiled-coil Myosin-like Bcl-2-Interacting Protein, ATG6, BECN1, GT197,


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Clone Host Grade Applications
Monoclonal Rabbit B IP IH IC
The Beclin-1 (BECN1) gene encodes a 60kD coiled-coil protein that interacts with the prototypic apoptosis inhibitor Bcl-2 (1). Beclin-1 promotes autophagy in autophagy-defective yeast with a targeted disruption of agp6/vps30, and in human MCF7 breast carcinoma cells. The autophagy-promoting activity of Beclin-1 in MCF7 cells is associated with inhibition of MCF7 cellular proliferation, in vitro clonigenicity and tumorigenesis. Endogenous Beclin-1 protein expression is frequently low in human breast epithelial carcinoma cell lines and tissue, but is expressed ubiquitously at high levels in normal breast epithelia (2). It has also been shown that Beclin 1 contains a leucine-rich nuclear export signal motif raising the possibility that its autophagy and/or tumor suppressor function may require regulated, CRM1-dependent, nucleocytoplasmic transport (3).
Catalog #B0981-23G
ApplicationsSuitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: 1:50
Immunocytochemistry: 1: 50
Western Blot: 1:5000
Optimal dilutions to be determined by the researcher.
Positive ControlAntigen standard for BECN1 (NM_003766) (transient overexpression lysate)
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No8J320
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-Glycine, pH 7.2, 0.15M sodium chloride, 0.05% BSA, 40% glycerol, 0.01% sodium azide.
PurityRabbit ascites
ImmunogenSynthetic peptide corresponding to residues near the C-terminus of human Beclin-1.
SpecificityRecognizes human Beclin-1 (Coiled-coil Myosin-like Bcl-2-Interacting Protein, ATG6, BECN1, GT197, VPS30). Species Crossreactivity: Does not react in Mouse or Rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesanti-ATG 6 antibody, anti-ATG6 antibody, anti-BECN 1 antibody, anti-BECN1 antibody, anti-Beclin1 antibody, anti-Coiled coil myosin like BCL2 interacting protein antibody, anti-GT197 antibody, anti-Protein GT197 antibody, anti-VPS 30 antibody, anti-VPS30 a

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