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You are here:Home » Antibodies » Abs to Autophagy » Anti -Beclin-1 (Beclin 1 (Coiled-coil Moesin-like BCL2-interacting Protein), Beclin1, BECN1, APG6, ATG6, ATG6 Autophagy-related 6 Homolog, Coiled-coil Myosin-like Bcl-2-Interacting Protein, GT197, Protein GT197, VPS30)

Anti -Beclin-1 (Beclin 1 (Coiled-coil Moesin-like BCL2-interacting Protein), Beclin1,
BECN1, APG6, ATG6, ATG6 Autophagy-related 6 Homolog, Coiled-coil Myosin-like
Bcl-2-Interacting Protein, GT197, Protein GT197, VPS30)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
Beclin1 is a 60kD member of the Beclin family of proteins. It is part of a lipid-kinase complex that includes UVRAG and PI3 and induces autophagy; in the presence of Bcl-2, autophagy is repressed. Beclin1 is widely expressed but abundantly found in mammary epithelium, glia and neurons. Human Beclin1 is 450aa in length and contains a Bcl-2 binding domain aa88-150, a nuclear export signal motif aa180-189, a coiled-coil region aa142-270, and an evolutionary conserved domain aa244-337. There is one potential alternate start site at Met88. Over aa12-239, human Beclin1 is 98aa identical to mouse Beclin1.
Catalog #B0981-23S
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2B
Clone No11n13
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant corresponding to aa12-239 from human Beclin1 expressed in E. coli (Q14457).
SpecificityRecognizes human Beclin1, human, mouse and rat. No cross-reactivity with recombinant human ATG3, 4A, 4B, 5, 7, 10, 12, or 16L1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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