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You are here:Home » Antibodies » Abs to Autophagy » Anti -Beclin-1 (Beclin 1 (Coiled-coil Moesin-like BCL2-interacting Protein), Beclin1, BECN1, APG6, ATG6, ATG6 Autophagy-related 6 Homolog, Coiled-coil Myosin-like Bcl-2-Interacting Protein, GT197, Protein GT197, VPS30)

Anti -Beclin-1 (Beclin 1 (Coiled-coil Moesin-like BCL2-interacting Protein), Beclin1,
BECN1, APG6, ATG6, ATG6 Autophagy-related 6 Homolog, Coiled-coil Myosin-like
Bcl-2-Interacting Protein, GT197, Protein GT197, VPS30)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
Beclin-1 is a novel Bcl-2-interacting cellular protein that may play a role in antiviral host defense. The beclin1 gene maps to a region approximately 150kb centromeric to BRCA1 on chromosome 17q21 that is commonly deleted in breast, ovarian, and prostate cancer. The protein has been proposed to coordinate both apoptosis and autophagy through direct interaction with anti-apoptotic family members Bcl-2 and Bcl-X(L). The protein contains a conserved BH3 domain, which is both necessary and sufficient for its interaction with Bcl-X(L). The protein is ubiquitously expressed. Beclin-1 deficiency disrupts neuronal autophagy and promotes neurodegeneration and AD-like disease.
Catalog #B0981-23X
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa53-72 (KPGETQEEETNSGEEPFIET) of human Beclin-1.
SpecificityRecognizes human Beclin-1. Species sequence homology: bovine, mouse, porcine, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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