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You are here:Home » Antibodies » Abs to Autophagy » Anti -Beclin-1 (Coiled-coil Myosin-like BCL2-interacting Protein, Protein GT197, BECN1, GT197)

Anti -Beclin-1 (Coiled-coil Myosin-like BCL2-interacting Protein, Protein GT197, BECN1,
GT197)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Beclin is a Bcl-2 binding protein. Its structure includes a Bcl-2 binding coiled-coil region, and a leucine-rich nuclear export signal (NES). Beclin protein colocalizes with intracytoplasmic organelles and nuclei in normal COS7 and MCF7 cells. Beclin interaction with Bcl-2 may be involved with host viral defense, since over expression of beclin inhibits Sindbis virus replication and expression of beclin lacking the Bcl-2 binding domain has no antiviral effects.
Catalog #B0981-23Z
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 1% BSA, 0.02% thimerosal, 50% glycerol.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa25 from mouse Beclin 1.
SpecificityRecognizes mouse Beclin 1 at ~53kD, ~100kD and ~110kD. Species Crossreactivity: human and porcine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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