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You are here:Home » Antibodies » Abs to Myosin » Anti -Beclin-1, NT (Coiled-coil Myosin-like Bcl-2-Interacting Protein)

Anti -Beclin-1, NT (Coiled-coil Myosin-like Bcl-2-Interacting Protein)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be
defective in tumor cells (1,2). Beclin-1, a coiled-coil Bcl-2- interacting protein homologous to the yeast autophagy gene apg6 (3,4), is a mammalian autophagy gene that can
inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors (5). Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and
mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death (6)
Catalog #B0981-25
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: .5-1ug’ml
Optimal dilutions to be determined by the researcher.
Positive Control293 cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide Beclin-117aa near the amino terminus of
human Beclin-1 (Genbank accession No. AAH10276).
SpecificityRecognizes human Beclin-1. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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