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Specifications

A derivative of Blebbistatin, a compound that blockes myosin II-dependent cell processes.
Catalog #	B1076-31
	As part of a defined medium for growth of human Pluripotent stem (hPS) cells, Blebbistatin acts as an inhibitor of nonmuscle myosin II (NMII) and enhances the survival of hPS cells.
	Preventing cell death of Human pluripotent stem (hPS) cells, such as human embryonic stem (hES) and induced pluripotent stem (hiPS) cells, has been a stumbling block to avenues of investigation of with these cell types. The most current culture methods for growing hPS cells require animal-derived materials like Matrigel, for coating the culture surfaces, without which hPS cells cannot adhere to the culture plate. The drawback in using these feeder cells is they can potentially contaminate hPS cells by introducing viruses and other unknown pathogens.
	The active enantiomer of Blebbistatin (so named because of its ability to block cell blebbing) is the (S)-(-)-Blebbistatin form. United States Biological offers the racemic mixture of Blebbistatin, along with the active (S)-(-) form and the inactive (R)-(+) form (which can be used as a negative control).
Melting Point	147-148°C
Solubility	Chloroform, Dichloromethane, DMSO, Ethyl Acetate, Methanol
Storage and Stability	May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Formula	C25H20N2O3
Form	Brown Solid
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
Due to the potential danger associated with the use of some of United States Biological biochemicals, all products should be handled by qualified personnel only, trained in laboratory procedures, and familiar with potential hazards. Information is not available on the possible hazards of many experimental compounds. The absence of a warning must not be interpreted as indication of safety. The ultimate responsibility for the proper handling of any and all chemicals lies with the user. All goods sold by United States Biological carry the condition that liability for any injury, loss or damage whatsoever to persons or real property resulting from the handling of the said goods lies with the user. Acceptance of our goods binds the customer to these terms.