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You are here:Home » Biochemicals » Biochem-Inhibitors » 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (GSK-3 Inhibitor I, TDZD-8)

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (GSK-3 Inhibitor I, TDZD-8)

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Specifications

Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione, also known as TDZD-8, is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK3b (IC50 =2nM). It binds to the active site of GSK3b. It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM).
Catalog #B1078-01E
Melting PointAs Reported
SolubilityAs Reported
Method for Determining IdentityProton NMR (CDCl3) Spectroscopic and Mass Spectrometric Analysis
TLC ConditionsAs Reported
Storage and StabilityMay be stored at RT for short-term only. Long-term storage is recommended at -20°C. Store under inert atmosphere in amber vial. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards 
All products should be handled by qualified personnel only, trained in laboratory procedures.
CAS Number327036-89-5
Molecular FormulaC10H10N2O2S
SourceSynthetic
Purity~90%
FormAs Reported
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesGSK-3? Inhibitor I, TDZD-8


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