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You are here:Home » Antibodies » Antibodies-Disease Markers » Anti -Bestrophin (BEST, Best Macular Dystrophy, BMD, Vitelliform Macular Dystrophy, VMD2)

Anti -Bestrophin (BEST, Best Macular Dystrophy, BMD, Vitelliform Macular Dystrophy, VMD2)


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Clone Host Grade Applications
Monoclonal Mouse B IF
Best macular dystrophy (BMD) or vitelliform macular dystrophy (VMD2), is an autosomal form of macular degeneration, characterized by a depressed light peak in the electrooculogram (EOG). It is inherited and has an early onset. Bestrophin is a 68kD basolateral plasma membrane protein encoded by the VMD2 gene. Bestrophin's function is still unknown, but data suggests that it is a chloride channel that plays a role in generating the altered EOG in Best disease patients. In addition, Bestrophin is a useful biochemical and histological marker of RPE (retinal pigment epithelial cells) cells.
Catalog #B1080-25B
Positive Control Pig RPE (Retinal Pigment Epithelium) whole cell extract
ApplicationsSuitable for use in Immunofluorescence and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No8J321
ConcentrationNot determined
FormSupplied as a liquid (ascites) containing 0.01% sodium azide
ImmunogenPartial recombinant protein [KDHMDPYWALENRDEAHS].
SpecificitySpecies Crossreactivity: Recognizes human, porcine, and monkey. This antibody does not work in rat. Other species have not been tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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