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Anti -Bestrophin (BEST, Best Macular Dystrophy, BMD, Vitelliform Macular Dystrophy, VMD2)
Anti -Bestrophin (BEST, Best Macular Dystrophy, BMD, Vitelliform Macular Dystrophy, VMD2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
|
B IF |
|
| Best macular dystrophy (BMD) or vitelliform macular dystrophy (VMD2), is an autosomal form of macular degeneration, characterized by a depressed light peak in the electrooculogram (EOG). It is inherited and has an early onset. Bestrophin is a 68kD basolateral plasma membrane protein encoded by the VMD2 gene. Bestrophin's function is still unknown, but data suggests that it is a chloride channel that plays a role in generating the altered EOG in Best disease patients. In addition, Bestrophin is a useful biochemical and histological marker of RPE (retinal pigment epithelial cells) cells. | | | Catalog # | B1080-25B | | Positive Control | Pig RPE (Retinal Pigment Epithelium) whole cell extract | | Applications | Suitable for use in Immunofluorescence and Western Blot. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1,k | | Clone No | 8J321 | | Host | Mouse | | Concentration | Not determined | | Form | Supplied as a liquid (ascites) containing 0.01% sodium azide | | Purity | Ascites | | Immunogen | Partial recombinant protein [KDHMDPYWALENRDEAHS]. | | Specificity | Species Crossreactivity: Recognizes human, porcine, and monkey. This antibody does not work in rat. Other species have not been tested. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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