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Specifications

Betacellulin (BTC) is a widely expressed EGF-related polypeptide growth factor, proteolytically processed into a soluble mature form, which acts as a potent inducer of mitosis in vascular smooth muscle cells and retinal pigment epithelial cells. BTC signals through binding to the homodimeric ErbB-1 and ErbB-4 receptors, but also appears to uniquely bind to and activate all known heterodimeric ErbB receptors.
Catalog #	B1081-40H
Source	Recombinant Betacellulin expressed in E.coli.
Activity	The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is 0.05ng/ml, corresponding to a specific activity of 2x10e7units/mg.
Applications	Suitable for use in Functional Assays. Other applications not tested.
Recommended Dilution	Optimal dilutions to be determined by the researcher.
Storage and Stability	Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight	9.0kD
Source	E.coli.
Purity	~98% by SDS PAGE and HPLC analysis. Endotoxin: 1EU/ug.
Form	Supplied as a lyophilized powder. Reconstitute with 200ul sterile dH2O .
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.