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You are here:Home » Molecular Biology » MB-Growth Factors-EGF » Betacellulin Recombinant, Human (BTC, Probetacellulin)

Betacellulin Recombinant, Human (BTC, Probetacellulin)


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Betacellulin (BTC) is a widely expressed EGF-related polypeptide growth factor, proteolytically processed into a soluble mature form, which acts as a potent inducer of mitosis in vascular smooth muscle cells and retinal pigment epithelial cells. BTC signals through binding to the homodimeric ErbB-1 and ErbB-4 receptors, but also appears to uniquely bind to and activate all known heterodimeric ErbB receptors.
Catalog #B1081-40H
SourceRecombinant Betacellulin expressed in E.coli.
ActivityThe ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is 0.05ng/ml, corresponding to a specific activity of 2x10e7units/mg.
ApplicationsSuitable for use in Functional Assays. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight9.0kD
Purity~98% by SDS PAGE and HPLC analysis. Endotoxin: 1EU/ug.
FormSupplied as a lyophilized powder. Reconstitute with 200ul sterile dH2O .
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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