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You are here:Home » Antibodies » Abs to Apoptosis » Anti -Bim (Apoptosis Facilitator, BAM, Bcl2 Interacting Mediator of Cell Death, Bcl-2-interacting Mediator of Cell Death, Bcl 2 Interacting Protein Bim, Bcl-2-interacting Protein Bim, Bcl 2 Like Protein 11, Bcl2-like Protein 11, Bcl 2 Related Ovarian Death Agon

Anti -Bim (Apoptosis Facilitator, BAM, Bcl2 Interacting Mediator of Cell Death,
Bcl-2-interacting Mediator of Cell Death, Bcl 2 Interacting Protein Bim, Bcl-2-interacting
Protein Bim, Bcl 2 Like Protein 11, Bcl2-like Protein 11, Bcl 2 Related Ovarian Death Agon

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E B IP IH
Apoptosis or programmed cell death is a physiological cellular process characterized by cell shrinkage, membrane blebbing, DNA fragmentation, and release of Cytochrome C from the mitochondria. It is utilized by the organism to get rid of unwanted cells, which is critical for normal development and homeostasis of an organism. Disregulation of normal apoptosis process have been implicated in a variety of diseases, including cancer, autoimmune diseases, viral infections, etc. Programmed cell death occurs through complex cascades of cell signaling in which Bcl-2 family members, among others, play an important role.The Bcl-2 family of proteins regulate apoptosis as well as execute death signals at the mitochondrion. Members of this family include both pro- and anti-apoptotic proteins that hare homology sequences called Bcl-2 Homology domains (BH1-4) which mediate dimer formation. The BH3 proteins, such as BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region, which is required for their apoptotic function. They may trigger release of death-inducing molecules such as Cytochrome C, Smac, and endonuclease G. Anti-apoptotic family members, including Bcl-2 and Bcl-XL, play inhibitory roles. Bcl-2 family proteins may form homodimers or heterodimers between pro- and anti-apoptotic members, the ratios of which determine the cell fate.
Applications:
Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested.
Catalog #B1090-02A
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No9G20
HostMouse
SourceHuman
Concentration~0.25mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
PurityPurified
ImmunogenSynthetic peptide corresponding to aa145-165 of human Bim.
SpecificityRecognizes human Bim. Species crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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