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You are here:Home » Antibodies » Abs to Enzymes, Reductase » Anti -Biliverdin IX alpha Reductase (BLVRA, Biliverdin reductase A, Biliverdin reductase A, BLVR, BVR, BVRA, BVR A)

Anti -Biliverdin IX alpha Reductase (BLVRA, Biliverdin reductase A, Biliverdin reductase
A, BLVR, BVR, BVRA, BVR A)

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Specifications

Clone Host Grade Applications
Polyclonal Chicken Affinity Purified B
Biliverdin Reductase (BLVR) is a ubiquitously expressed, small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The first step of this process is catalyzed by heme oxygenase, an enzyme that converts heme to iron, carbon monoxide, and biliverdin. BLVR is unique among all enzymes to date in being dual pH/dual cofactor-dependent, as it requires NADH (pH 6.7) or NADPH (pH 8.7) as an electron donor. There are two isoforms of BLVR, Biliverdin-IX alpha-reductase (BLVRA), the major component of human adult liver, and biliverdin IX beta-reductase (BLVRB), found predominantly in fetal liver. The product of BLVR, bilirubin, is an important biological antioxidant, however it is also a neurotoxin and the cause of kernicterus. In addition to being an antioxidant, it inhibits kinase activity and the activity of enzymes such as protein kinase C and NADPH oxidase.
Catalog #B1150-01
Application(s)Suitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.1ug/ml; Detects an ~40kD protein representing BLVRA from HeLa cell extract.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgY
HostChicken
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 1mg/ml BSA and 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenPurified human Biliverdin IX alpha reductase expressed in E. coli.
SpecificityRecongizes BLVRA. Species Crossreactivity: Human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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