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You are here:Home » Antibodies » Antibodies-Proteins » Anti -Bin1

Anti -Bin1


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IP IH
Bin1 is a ubiquitously expressed protein that interacts with the N-terminal region of the oncoprotein Myc. It inhibits cell transformation by Myc and has been implicted in Myc-mediated apoptosis. Bin1 is structurally related to amphiphysin, a breast cancer associated autoimmune antigen, and RVS167, a negative regulator of cell cycle in yeast. Bin1 is frequently absent in carcinoma cells and the gene maps to a hot spot for deletion in prostate cancer. Thus Bin1 has the features of a tumor suppressor and may play a role in apoptosis or cell cycle regulation.
Catalog #B1200
ApplicationsSuitable for use in ELISA, Western Blot, Immunoprecipitaton and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionWestern Blot: 0.5-2 ug/ml detects Bin1 in a RIPA lysate of cells.
Immunohistochemistry: Gives positive staining for Bin1 in C2C12, LNCap, HeLa, and Rat1 cells.
Optimal dilutions to be determined by the researcher.
*Recommended secondary antibodiesI1904-06C: IgG, H&L (HRP) (X-Adsorbed) Pab Gt xMo
I1904-06H IgG, H&L (HRP) (X-Adsorbed) Pab Gt xMo
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer
Clone TypeMonoclonal
Clone No0.T.07
FormSupplied as solution in 0.1M Tris-glycine, pH 7.4, containing 0.05% sodium azide.
PurityProtein G purified
ImmunogenPartial fusion protein corresponding to amino acids 189-398 of human Bin1.
SpecificityRecognizes Bin1 of approximately 56kD and another protein of approximately 75kD, which may be the phosphorylated form of Bin1. Species Crossreactivity: Rat and mouse.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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