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You are here:Home » Antibodies » Abs to Neuroscience » Anti -BIRC1, CT (Neuronal Apoptosis Inhibitory Protein, NAIP, PSINAIP, Baculoviral IAP Repeat-Containing Protein 1)

Anti -BIRC1, CT (Neuronal Apoptosis Inhibitory Protein, NAIP, PSINAIP, Baculoviral IAP
Repeat-Containing Protein 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Neuronal Apoptosis Inhibitory Protein (NAIP) also known as BIRC1, is a 1406aa intracellular protein belonging to the IAP family. NAIP functions in the prevention of neuron apoptosis induced by various signals. It was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy. NAIP, unlike other IAPs, requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO, this suggests that NAIP is unique among the IAPs in its regulation of activity. NAIP is expressed in motor, but not sensory neurons, it is also found in the liver, placenta, and to a lesser extent, spinal cord.
Catalog #B2049-80D1
ApplicationsSuitable for use in Immunohistochemistry (paraffin) and Western Blot. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 5ug/ml
Western Blot: 0.5-1ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman placenta
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to a 13aa sequence from the C-terminus of human BIRC1.
SpecificityRecognizes human BIRC1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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