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You are here:Home » Antibodies » Abs to Neuroscience » Anti -BIRC1 (Baculoviral IAP Repeat-containing Protein 1, Neuronal Apoptosis Inhibitory Protein, NAIP)

Anti -BIRC1 (Baculoviral IAP Repeat-containing Protein 1, Neuronal Apoptosis Inhibitory
Protein, NAIP)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E
Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neuro-degenerative disorder spinal muscular atrophy. Members of the IAP family contain one to three copies of an approximately 70aa motif termed baculovirus IAP repeat (BIR); these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules. Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO, suggesting that NAIP is unique among the IAPs in its regulation of its activity. Although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported.
Catalog #B2049-80E
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to QKASDERISQFDHN-C, from NAIP, at N-terminal (NP_004527.2).
SpecificityRecognizes NAIP. Species sequence homology: Human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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