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You are here:Home » Antibodies » Abs to Neuroscience » Anti -BIRC1 (Baculoviral IAP Repeat Containing 1, Baculoviral IAP Repeat-containing Protein 1, BIRC1, Birc1a, FLJ42520, Neuronal Apoptosis Inhibitory Protein, NLR Family Apoptosis Inhibitory Protein, NAIP, NAIP1, NLR Family BIR Domain Containing 1, NLRB1, Nucle

Anti -BIRC1 (Baculoviral IAP Repeat Containing 1, Baculoviral IAP Repeat-containing
Protein 1, BIRC1, Birc1a, FLJ42520, Neuronal Apoptosis Inhibitory Protein, NLR Family
Apoptosis Inhibitory Protein, NAIP, NAIP1, NLR Family BIR Domain Containing 1, NLRB1,
Nucle

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B
Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy (1,2). Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR); these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules (reviewed in 3). Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO (4), suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported (5).
Catalog #B2049-81A
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1 ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control
PC-3 cell lysate
Storage and StabilityMay be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs Reported
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by ammonium sulfate precipitation.
ImmunogenSynthetic peptide corresponding to 13 amino acids at the C-terminus of human NAIP (AAC52047).
SpecificityRecognizes human NAIP.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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