Anti -BIRC1 (Baculoviral IAP Repeat Containing 1, Baculoviral IAP Repeat-containing
Protein 1, BIRC1, Birc1a, FLJ42520, Neuronal Apoptosis Inhibitory Protein, NLR Family
Apoptosis Inhibitory Protein, NAIP, NAIP1, NLR Family BIR Domain Containing 1, NLRB1,
Nucle
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
B |
|
| Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy (1,2). Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR); these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules (reviewed in 3). Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO (4), suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported (5). | | | Catalog # | B2049-81A | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5-1 ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | | | PC-3 cell lysate | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | N/A | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As Reported | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified by ammonium sulfate precipitation. | | Immunogen | Synthetic peptide corresponding to 13 amino acids at the C-terminus of human NAIP (AAC52047). | | Specificity | Recognizes human NAIP. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -BIRC1 (Baculoviral IAP Repeat Containing 1, Baculoviral IAP Repeat-containing Protein 1, BIRC1, Birc1a, FLJ42520, Neuronal Apoptosis Inhibitory Protein, NLR Family Apoptosis Inhibitory Protein, NAIP, NAIP1, NLR Family BIR Domain Containing 1, NLRB1, Nucle |
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