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You are here:Home » Antibodies » Abs to Transcription Factors, Zinc (Ring) Finger » Anti -BIRC3 (Baculoviral IAP Repeat-containing Protein 3, Apoptosis Inhibitor 2, API2, C-IAP2, IAP Homolog C, Inhibitor of Apoptosis Protein 1, IAP-1, hIAP-1, hIAP1, RING Finger Protein 49, TNFR2-TRAF-signaling Complex Protein 1, API2, IAP1, MIHC, RNF49)

Anti -BIRC3 (Baculoviral IAP Repeat-containing Protein 3, Apoptosis Inhibitor 2, API2,
C-IAP2, IAP Homolog C, Inhibitor of Apoptosis Protein 1, IAP-1, hIAP-1, hIAP1, RING Finger
Protein 49, TNFR2-TRAF-signaling Complex Protein 1, API2, IAP1, MIHC, RNF49)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Catalog #B2050-01P
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:32,000
Western Blot: 0.1-0.3ug/ml, lysates of cell line HeLa observed on ~70kD bands
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-SQPTFPSSVT, fromhuman BIRC3, at the internal region of the protein (NP_001156.1).
SpecificityRecognizes human BIRC3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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