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You are here:Home » Biochemicals » Biochem-Antibiotics » Bleomycin complex (as sulfate salts) (Blenoxane, Bleo, Blexane)

Bleomycin complex (as sulfate salts) (Blenoxane, Bleo, Blexane)

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Specifications

Bleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2 and typically represent >90% of the total weight with the remainder comprising the minor analogues. Bleomycins have found clinical application in the treatment of a range of tumors. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo- enzyme that induces DNA cleavage.
Catalog #B2105-59
Solubility Soluble in water, methanol with moderate ethanol solubility
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number9041-93-4
Molecular FormulaC55H84N17O21S+. H2SO4
Molecular Weight1513.6
SourceStreptomyces sp. MST-AS4458
Purity~99%
FormSupplied as an off-white solid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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