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You are here:Home » Antibodies » Abs to Transcription Factors, Zinc (Ring) Finger » Anti -Blimp-1 (BLIMP 1, BLIMP1, B Lymphocyte Induced Maturation Protein 1, Positive Regulatory Domain I Binding Factor 1, PR Domain Containing 1, PRDI BF1, PRDM1)

Anti -Blimp-1 (BLIMP 1, BLIMP1, B Lymphocyte Induced Maturation Protein 1, Positive
Regulatory Domain I Binding Factor 1, PR Domain Containing 1, PRDI BF1, PRDM1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH IC IF
Blimp-1 (B lymphocyte maturation protein-1) is a nuclear protein with five zinc fingers in its carboxy terminus. It is a transcriptional repressor that is both required and sufficient to trigger terminal differentiation of B lymphocytes and monocyte/macrophages. Blimp-1 is expressed in, and may be required for terminally differentiated epithelial cells, retinal neurons and other lineage cells. It has also been implicated in the repression of beta-interferon (IFN-beta) and c-myc gene expression.
Catalog #B2106-70
ApplicationsSuitable for use in Immunofluorescence, Flow Cytometry, ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested.
Recommended DilutionImmunofluorescence/Immunocytochemistry: 1:50-1:200
Flow Cytometry: 8ug/ml where cells are used at 2x10e6/ml
Western Blot: 1:1000
Immunohistochemistry (Paraffin): 1:200
Optimal dilutions to be determined by the researcher.
Positive ControlP3X (murine plasmocytoma) cell lysates
Cellular LocalizationNuclear
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8J333
HostMouse
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 150mM sodium chloride, 0.1% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenA fragment of the mouse Blimp-1 (residues 199-409).
SpecificityRecognizes mouse Blimp-1 at ~98kD and ~80kD (beta form). Species Crossreactivity: human and porcine (see Specific Reference).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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