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Abs to Transcription Factors, Zinc (Ring) Finger
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Anti -Blimp-1 (BLIMP 1, BLIMP1, B Lymphocyte Induced Maturation Protein 1, Positive Regulatory Domain I Binding Factor 1, PR Domain Containing 1, PRDI BF1, PRDM1)
Anti -Blimp-1 (BLIMP 1, BLIMP1, B Lymphocyte Induced Maturation Protein 1, Positive
Regulatory Domain I Binding Factor 1, PR Domain Containing 1, PRDI BF1, PRDM1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IH IC IF |
|
| Blimp-1 (B lymphocyte maturation protein-1) is a nuclear protein with five zinc fingers in its carboxy terminus. It is a transcriptional repressor that is both required and sufficient to trigger terminal differentiation of B lymphocytes and monocyte/macrophages. Blimp-1 is expressed in, and may be required for terminally differentiated epithelial cells, retinal neurons and other lineage cells. It has also been implicated in the repression of beta-interferon (IFN-beta) and c-myc gene expression. | | | Catalog # | B2106-70 | | Applications | Suitable for use in Immunofluorescence, Flow Cytometry, ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. | | Recommended Dilution | Immunofluorescence/Immunocytochemistry: 1:50-1:200 | | Flow Cytometry: 8ug/ml where cells are used at 2x10e6/ml | | Western Blot: 1:1000 | | Immunohistochemistry (Paraffin): 1:200 | | Optimal dilutions to be determined by the researcher. | | Positive Control | P3X (murine plasmocytoma) cell lysates | | Cellular Localization | Nuclear | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 8J333 | | Host | Mouse | | Source | Mouse | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 150mM sodium chloride, 0.1% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | A fragment of the mouse Blimp-1 (residues 199-409). | | Specificity | Recognizes mouse Blimp-1 at ~98kD and ~80kD (beta form). Species Crossreactivity: human and porcine (see Specific Reference). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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