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You are here:Home » Antibodies » Abs to Proteins » Anti -BMAL1 (aryl hydrocarbon receptor nuclear translocator-like, Aryl hydrocarbon receptor nuclear translocator-like protein 1, Basic-helix-loop- helix-PAS Protein MOP3, bHLHe5, bHLH-PAS Protein JAP3, BMAL1, BMAL1c, Brain and Muscle ARNT-like 1, JAP3, Member o

Anti -BMAL1 (aryl hydrocarbon receptor nuclear translocator-like, Aryl hydrocarbon
receptor nuclear translocator-like protein 1, Basic-helix-loop- helix-PAS Protein MOP3,
bHLHe5, bHLH-PAS Protein JAP3, BMAL1, BMAL1c, Brain and Muscle ARNT-like 1, JAP3, Member o

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. BMAL1 is the only component of the mammalian circadian clock whose sole deletion in a mouse model generates arrhythmicity. In addition to defects in the clock, these BMAL1 null-mice also have reproductive problems are small in stature, age quickly and have progressive arthropathy that results in having less overall locomotor activity than wild type mice. Recent phenotyping data suggests that BMAL1 and its partner Clock also play a role in regulation of glucose homeostasis and metabolism. Finally, BMAL1, NPAS2, and PER2 have been associated with seasonal affective disorder in humans. BMAL1 transcription is circadian and reciprocally regulated by NR1D1 (Rev-erb-alpha) and RORA, which establishes a second interlocking loop in the mammalian circadian clock.
Catalog #B2179-02
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:5000
Optimal dilutions to be determined by the researcher.
Positive ControlHeLa nuclear extract tissue lysate.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 0.1M Tris-Glycine, pH7.4, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to he internal domain of BMAL1 (KLH). Cellular Localization: Nucleus.
SpecificityRecognizes the internal domain of human BMAL1. Species sequence homology: mouse, rat, opposum, bovine, primate, monkey.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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