Anti -BMAL1, acetylated (Lys538) (aryl hydrocarbon receptor nuclear translocator-like,
Aryl hydrocarbon receptor nuclear translocator-like protein 1, Basic-helix-loop- helix-PAS
Protein MOP3, bHLHe5, bHLH-PAS Protein JAP3, BMAL1, BMAL1c, Brain and Muscle ARNT-l
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. BMAL1 is the only component of the mammalian circadian clock whose sole deletion in a mouse model generates arrhythmicity. In addition to defects in the clock, these BMAL1 null-mice also have reproductive problems, are small in stature, age quickly and have progressive arthropathy that results in having less overall locomotor activity than wild type mice. Recent phenotyping data suggests that BMAL1 and its partner Clock also play a role in regulation of glucose homeostasis and metabolism. Finally, BMAL1, NPAS2, and PER2 have been associated with seasonal affective disorder in humans. BMAL1 transcription is circadian and reciprocally regulated by NR1D1 (Rev-erb¬alpha) and RORA, which establishes a second interlocking loop in the mammalian circadian clock. | | | Catalog # | B2179-02A | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000 | | Optimal dilutions to be determined by the researcher. | | Positive Control | Transfected HEK293/myc-BMAL1/empty vector and HEK293/myc-BMAL1/myc-CLOCK treated with Nicotinamide. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Mouse | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | BMAL1 acetylated at Lysine538 (KLH). Epitope: C-Terminus. | | Specificity | Recognizes mouse BMAL1 acetylated at Lysine 538 at ~95kD. Species sequence homology: rat, opossum, porcine, equine and primate. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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