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You are here:Home » Antibodies » Abs to Transcription Factors, Zinc (Ring) Finger » Anti -Bmi-1 (RNF51, MGC12685, BUP, Polycomb Group RING Finger Protein 4)

Anti -Bmi-1 (RNF51, MGC12685, BUP, Polycomb Group RING Finger Protein 4)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IC IF
The Bmi1 oncogene has been shown to induce telomerase activity and immortalize human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Bmi1 is also important in maintaining stem cells' ability to self renew. It has also been termed an oncogene with aberrant expression in various carcinomas. It has been shown to be a negative regulator of p19Arf, Ink4a (p14Arf) and tp53 known tumor repressors. Ablation of Bmi1 is required for short term survival of cancer cells.
Catalog #B2185-01E
Positive Control Human and mouse skeletal muscle
ApplicationsSuitable for use in Western Blot, Immunocytochemistry and Immunofluorescence. Other applications not tested.
Recommended DilutionWestern Blot: A band is seen at ~37kD. Some less intense non-specific bands are also present.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide made to an internal region (within residues 1-100) of the human Bmi1 protein. [Swiss-Prot# P35226]. Cellular Localization: Nuclear
SpecificityRecognizes human Bmi-1. Species Crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesMurine Leukemia Viral (bmi 1) Oncogene Homolog, Oncogene BMI 1, PCGF4, Polycomb Complex Protein BMI 1, RING Finger Protein 51


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