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You are here:Home » Antibodies » Abs to Proteins » Anti -BOK (Bcl-2-related Ovarian Killer Protein, hBOK, Bcl-2-like Protein 9, Bcl2-L-9, BCL2L9)

Anti -BOK (Bcl-2-related Ovarian Killer Protein, hBOK, Bcl-2-like Protein 9, Bcl2-L-9,
BCL2L9)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
BOK (Bcl-2-related ovarian killer protein; also Bcl2L9 and Mtd) is a 27kD member of the Bax subgroup of the Bcl-2 family of molecules. It is expressed in spermatocytes, ovarian granulosa cells and liver cells. BOK is activated by E2F proteins, and sensitizes replicating cells to apoptosis when under stress. It is normally found in the cytosol, and upon activation, becomes incorporated into mitochondrial membranes. Human BOK is 212aa in length and contains one BH4 domain (aa32-44), one BH3 domain (aa66-82), a BH1 domain (aa112-131) and a BH2 domain (aa164-178). A potential transmembrane span has been identified between aa189-210. BOK heterodimerizes with Mcl-1, BHRF-1, Bfl-1 and Bnip3, and is known to form heterooligomers. There are two potential splice variants. One contains an alternative start site at Met145, while another shows a five aa substitution for aa117-212. Over aa15-123, human BOK shares 94% aa identity with mouse BOK.
Catalog #B2530-01A
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS, 0.02% sodium azide. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with sterile PBS, 0.02% sodium chloride.
PurityPurified by immunoaffinity chromatography.
ImmunogenE.coli-derived recombinant human BOK (aa15-123).
SpecificityRecognizes human BOK. Species Crossreactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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