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You are here:Home » Antibodies » Abs to Hormones, Steroids » Anti -Bombesin (BN, Gastrin Releasing Peptide, Gastrin-releasing Peptide, GRP, Neuromedin C, Neuromedin-C, Pre-progastrin Releasing Peptide, PreproGRP, ProGRP)

Anti -Bombesin (BN, Gastrin Releasing Peptide, Gastrin-releasing Peptide, GRP, Neuromedin
C, Neuromedin-C, Pre-progastrin Releasing Peptide, PreproGRP, ProGRP)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH IF
Bombesin (BN) is a tetradecapepide (Pyro-ENR LGN QWA VGH LM-amide) that was originally isolated from frog skin. Several BN-related peptides have been isolated from amphibians and classified into three subfamilies: Bombesin, ranatensin and phyllolitorin based upon the last three C-terminal residues. Two BN-like peptides have been identified in mammals: NMB (neuromedin B) in the ranatensin family and GRP (gastrin-releasing peptide) in the BN-family. BN-family of G-protein coupled receptors include at least four receptor subtypes: The GRP-preferring receptors (GRP-R or bb2), the NMB-preferring receptors (NMB-R or bb1) and Bombesin receptor subtype 3 (BRS-3 or bb4). These receptors share ~50% amino acid homology and bind bombesin. However, BRS-3 has much lower affinity for BN than GRP-R and NMB-R. Mammalian BN-like peptides are widely distributed in the brain and gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine activities, metabolism and behavior. Most recently, BRS-3 deficient mice have been shown to develop mild obesity, associated with hypertension, and impairment of glucose metabolism, reduced metabolic rate, increased feeding efficiency and subsequent hyperphagia.
Catalog #B2550-05
ApplicationsSuitable for use in Immunofluorescence and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunofluorescence: 1:30-1:300
Immunohistochemistry (Paraffin): 1:400-1:2000. Treatment of tissues in Bouinís fixative is recommended.
Optimal dilutions to be determined by the researcher.
Positive ControlHuman fetal lung
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
ConcentrationNot determined.
FormSupplied as a liquid in PBS, 1% BSA, 0.09% sodium azide.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to mature full-length bombesin (BSA).
SpecificityRecognizes Bombesin. Reacts with amphibian bombesin and its mammalian and avian homologs. Species Crossreactivity: Chicken, human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesGastric Releasing Peptide, GRP10, GRP-10


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