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B2553-03L Rabbit Anti-Bmp1, CT (Bone Morphogenetic Protein 1, BMP-1, Procollagen C-proteinase, PCP, Mammalian Tolloid Protein, mTld, PCOLC)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P13497
Isotype
IgG
Grade
Purified
Applications
E IHC WB
Crossreactivity
Hu Mo
Shipping Temp
Blue Ice
Storage Temp
-20°C

The BMP1 locus encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, BMP1 encodes a protein that is not closely related to other known growth factors. BMP1 protein and procollagen C proteinase (PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone formation, are identical. PCP or BMP1 protein cleaves the C-terminal propeptides of procollagen I, II, and III and its activity is increased by the procollagen C-endopeptidase enhancer protein. The BMP1 gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region.

Applications
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilutions
Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:50-1:100 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 957-986 in the C-terminal region of human Bmp1
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by ammonium sulfate precipitation
Specificity
Recognizes human Bmp1. Species Crossreactivity: mouse
References
1. Leighton, M., et al., J. Biol. Chem. 278(20):18478-18484 (2003). 2. Hartigan, N., et al., J. Biol. Chem. 278(20):18045-18049 (2003). 3. Garrigue-Antar, L., et al., J. Biol. Chem. 277(45):43327-43334 (2002). 4. Rattenholl, A., et al., J. Biol. Chem. 277(29):26372-26378 (2002). 5. Janitz, M., et al., J. Mol. Med. 76(2):141-146 (1998).
USBio References
No references available
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