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You are here:Home » Growth Factors, Cytokines » Growth Factors-BMP » Bone Morphogenetic Protein 2, Recombinant, Human (BMP2)

Bone Morphogenetic Protein 2, Recombinant, Human (BMP2)

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Specifications

BMP-2 belongs to the Bone-growth regulatory factors that are members of the transforming growth factor-beta (TGF-beta) superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins. Recombinant Human Bone Morphogenetic protein-2 produced in E. coli is a homodimeric, non-glycosylated, polypeptide chain containing 115 amino acids and having a molecular mass of 26018D.
Catalog #B2553-06D
Endotoxin 0.01ng/ug or 0.1EU/ug as per LAL.
Biological Activity BMP-2 is fully biologically active when compared to standard. The ED50 as determined by the cytolysis of MC3T3-E1 cells is less then 50ng/ml.
AA SequenceMQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O, aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight2.6kD
SourceRecombinant, human, E. coli
Purity~95% Analysis by RP-HPLC, Reducing and non-reducing SDS-PAGE.
FormSupplied as a lyophilized powder. Reconstitute with sterile dH2O PBS to 0.1-1mg/ml, which can be further diluted into other aqueous solutions.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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