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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -Bone Morphogenetic Protein 4 (BMP4, DVR4)

Anti -Bone Morphogenetic Protein 4 (BMP4, DVR4)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E B IC
Bone Morphogenic Protein 4 is a polypeptide belonging to the TGF-beta superfamily of proteins. It, like other bone morphogenetic proteins, is involved in bone and cartilage development, specifically tooth and limb development and fracture repair. It has been shown to be involved in muscle development, bone mineralization and uteric bud development. BMP4 has also been implicated in Fibrodysplasia Ossificans Progressiva in which it is underexpressed. In human embryonic development, BMP4 is a critical signalling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP4 is secreted from the dorsal portion of the notochord. It acts in concert with sonic hedgehog (released from the ventral portion of the notochord) to establish a dorsal-ventral axis for the differentiation of later structures. BMP4 stimulates differentiation of overlying ectodermal tissue. Inhibition of the BMP4 signal (by chordin, noggin or follistatin) causes the ectoderm to differentiate into the neural plate. If these cells also receive signals from FGF, they will differentiate into the spinal cord; in the absence of FGF the cells become brain tissue.
Catalog #B2553-20
ApplicationsSuitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionsWestern Blot (Reduced and Non-reduced): Using osteoinductive cells, i.e. BFP and Saos-2.
Immunocytochemistry: Using osteoinductive cells, i.e. BFP and Saos-2.
Optimal dilutions to be determined by the researcher.
Recommended Positive ControlMouse brain extract
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No3h2.3
HostMouse
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.6, 0.1% sodium azide.
PurityPurified
ImmunogenRecombinant protein corresponding to mouse BMP4
SpecificityRecognizes mouse BMP4. Recognizes human and mouse BMP4 in both reduced and non-reduced conditions. Does not crossreact with human BMP2 or human TGF-b1.
Species CrossreactivityHuman and rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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