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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -Bone Morphogenetic Protein 4 (BMP 4, BMP4, BMP-4, BMP 2B, BMP2B, BMP-2B, BMP2B1, DVR4, ZYME)

Anti -Bone Morphogenetic Protein 4 (BMP 4, BMP4, BMP-4, BMP 2B, BMP2B, BMP-2B, BMP2B1,
DVR4, ZYME)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
There are at least 20 structurally and functionally related BMPs, which are members of the TGF-beta superfamily. BMPs were originally identified as protein regulators of cartilage and bone formation. They are also involved in embryogenesis and morphogenesis of various tissues and organs. BMPs regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. Similar to other TGF-beta family proteins, BMPs are highly conserved across animal species.
Catalog #B2553-20B
BMP4 is implicated in fibrodysplasia ossificans progressive. It is reported to be uniquely overexpressed in lymphoblastoid cells and preosseous fibroproliferative lesions. BMPs 1 to 6 are also reported to be expressed in prostatic adenocarcinomas with BMPs 1 to 5 also expressed in both benign and prostatic hyperplasia and ocular melanoma.
Smad1 translocation to the nucleus is observed after the addition of BMP4 (also designated BMP2B), suggesting that BMP4 may play a role in activation of the Smad pathway. BMP is secreted into the extracellular matrix.
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: Paraffin
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid.
PurityPurified by immunoaffinity chromatography.
ImmunogenKLH Coupled-synthetic peptide-Amino acids: 20 to 34 of human BMP4.
SpecificityRecognizes human BMP4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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