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You are here:Home » Molecular Biology » Growth Factors-BMP » Bone Morphogenetic Protein 4, 293-408aa, Recombinant, Human (BMP4, DVR4)

Bone Morphogenetic Protein 4, 293-408aa, Recombinant, Human (BMP4, DVR4)

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Specifications

Bone morphogenetic protein 4 (BMP-4) is a member of the bone morphogenetic protein family which belongs to the TGF- superfamily. This protein is a vital regulatory molecule that functions throughout bone and cartilage development, specifically tooth development, limb formation, bone induction, and fracture repair. In human embryonic development, BMP- 4 is required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. And it is overexpressed in patients with fibrodysplasia ossificans progressiva. Recombinant BMP-4 was expressed as insoluble protein aggregate in E. coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Catalog #B2553-21A
Endotoxin Level 1.0 EU per 1 ug of protein (determined by LAL method)15% SDS-PAGE (3ug)
Molecular Weight 13.2kD (117 aa)
AA SequencesMSPKHHSQRA RKKNKNCRRH SLYVDFSDVG WNDWIVAPPG YQAFYCHGDC PFPLADHLNS TNHAIVQTLV NSVNSSIPKA CCVPTELSAI
SMLYLDEYDK VVLKNYQEMV VEGCGCR
Storage and StabilityFor long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight13.2kD
SourceE. coli
Purity95% by SDS-PAGE
Concentration~0.5mg/ml
FormSupplied as a liquid in 10mM sodium citrate buffer, pH 3.5, 10% glycerol.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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