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Bone Morphogenetic Protein 4, 293-408aa, Recombinant, Human (BMP4, DVR4)
Bone Morphogenetic Protein 4, 293-408aa, Recombinant, Human (BMP4, DVR4)
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| Bone morphogenetic protein 4 (BMP-4) is a member of the bone morphogenetic protein family which belongs to the TGF- superfamily. This protein is a vital regulatory molecule that functions throughout bone and cartilage development, specifically tooth development, limb formation, bone induction, and fracture repair. In human embryonic development, BMP- 4 is required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. And it is overexpressed in patients with fibrodysplasia ossificans progressiva. Recombinant BMP-4 was expressed as insoluble protein aggregate in E. coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. | | | Catalog # | B2553-21A | | Endotoxin Level | 1.0 EU per 1 ug of protein (determined by LAL method)15% SDS-PAGE (3ug) | | Molecular Weight | 13.2kD (117 aa) | | AA Sequences | MSPKHHSQRA RKKNKNCRRH SLYVDFSDVG WNDWIVAPPG YQAFYCHGDC PFPLADHLNS TNHAIVQTLV NSVNSSIPKA CCVPTELSAI | | SMLYLDEYDK VVLKNYQEMV VEGCGCR | | Storage and Stability | For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 13.2kD | | Source | E. coli | | Purity | 95% by SDS-PAGE | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in 10mM sodium citrate buffer, pH 3.5, 10% glycerol. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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