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You are here:Home » Antibodies » Antibodies-Growth Factors, Cytokines » Anti -Bone Morphogenic Protein 6 (BMP6, vgr-1, Vegetal Related, DVR-6, Decapentaplegic Vegetal Related)

Anti -Bone Morphogenic Protein 6 (BMP6, vgr-1, Vegetal Related, DVR-6, Decapentaplegic
Vegetal Related)


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Clone Host Grade Applications
Monoclonal Mouse Purified IH
Bone morphogenic protein 6 (BMP-6) is a member of the TGF-beta superfamily of cytokines regulating homeotic gene expression, embryonic development and neurogenesis. Pre-incubation with amino-terminal peptide 1-29 of BMP-6 inhibits binding of the monoclonal to tissue sections. Pre-incubation with other amino-terminal synthetic peptides of human BMP-7, BMP-4, BMP-3 and BMP-2 as well as irrelevant peptides does not inhibit specific tissue staining.
Catalog #B2553-30
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry: 1-2ug/ml. Fixation: formaldehyde, paraffin. Tissue pretreatment: microwave treatment (6 x 5) min is required.
Optimal dilutions to be determined by the researcher.
Antigen DistributionPositive staining can be observed in embryonic and adult central nervous system. Rat radial glial cells of the developing central nervous system from E11 to E19. In rat peripheral nerves a selective intracellular immunoreactivity can be found in the perinuclear region of most Schwann cells which form myelin sheath. However, some Schwann cells are negative for this antibody. BMP-6 can also be found in a variety of other tissues and cell types, notably keratinizing epithelial cells. Smooth muscle cells, characterized by desmin positivity, were positively stained in normal tissues and in atherosclerotic plaques. Macrophages (CD68+) and endothelial cells were negative.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No2Q23
Concentration~0.2mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, pH 7.2, 5mg/ml BSA, 0.09% sodium azide. Reconstitute with 500ul sterile ddH2O.
ImmunogenSynthetic peptide corresponding to vgr 1-29C conjugated to KLH.
SpecificityRecognizes human BMP-6. Species Crossreactivity: rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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