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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -Bone Morphogenic Protein 6 (BMP6, vgr-1, Vegetal Related, DVR-6, Decapentaplegic Vegetal Related)

Anti -Bone Morphogenic Protein 6 (BMP6, vgr-1, Vegetal Related, DVR-6, Decapentaplegic
Vegetal Related)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B N
Bone Morphogenetic Proteins (BMP) are members of the TGF beta superfamily of cytokines that affect bone and cartilage formation. Similar to other TGF beta family proteins, BMPs are highly conserved across animal species. BMPs are involved in embryogenesis and morphogenesis of various tissues and organs. BMP6 is an autocrine stimulator of chondrocyte differentiation and has been implicated in the development of embryonic kidney and urinary systems. It is involved in liver growth and differentiation, keratinocyte differentiation, and regulation of neuronal tissue development. BMP6 expression is localized to smooth muscle cells of normal cerebral blood vessels, intimal plaques and atherosclerotically changed blood vessels, further suggesting a role as a regulator of developing tissues.
Catalog #B2553-30J
ApplicationsSuitable for use in ELISA, Neutralization and Western Blot. Other applications not tested.
Recommended DilutionsELISA: 0.5-1.0 ug/ml. The detecton limit for recombinant human BMP-6 is ~6.2ng/well.
Western Blot: 1-20ug/ml. The detection limit for recombinant human BMP6 is ~ 20ng/lane under non-reducing conditions.
Neutralization: 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No8J349
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 5% trehalose.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant full length human Bone Morphogenic Protein 6 expressed in CHO cells. Cellular Localization: Secreted
SpecificityRecognizes human Bone Morphogenic Protein 6. Shows <5% crossreactivity with recombinant human BMP5 and BMP7 and no crossreactivity with recombinant human BMP2 and BMP4 under reducing conditions.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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