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Specifications

Clone Host Grade Applications Polyclonal Rabbit Purified B

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, and CCR2b in the chemokine receptor family have been identified as HIV coreceptors. An orphan G protein-coupled receptor was recently cloned and designated Bonzo, STRL33 and TYMSTR, and identified as HIV and SIV coreceptor (1-4). Bonzo/STRL33 is used by SIV, HIV-2 and HIV-1. The messenger RNA of Bonzo/STRL33 is expressed in lymphoid tissues and activated peripheral blood lymphocytes.
Catalog #	B2555
This polyclonal antibody can be used for detection of Bonzo expression by Western blot at 1	1000 dilution. Whole cell lysate from SW1353 cells can be used as positive control.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	0.5mg/ml
Form	Supplied as a liquid in PBS, 0.02% sodium azide.
Purity	Purified IgG
Immunogen	Peptide corresponding to amino acids 319 to 338 of human origin (1,2). The sequence of this peptide is identical to those of macaque and African green monkey.
Specificity	Recognizes human Bonzo (CT).
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.