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Anti -BORIS (Brother of the Regulator of Imprinted Sites)
Anti -BORIS (Brother of the Regulator of Imprinted Sites)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| BORIS (Brother of the Regulator of Imprinted Sites) also known as CCTC-binding factor-like protein, is normally only expressed in the testis and expressed in a mutually exclusive manner with CTCF during male germ cell development. However, previous studies have shown that BORIS is abnormally activated in a wide range of human cancers. Expression of BORIS in normally BORIS-negative cells promotes cell growth that may lead to transformation. BORIS maps to the cancer-associated amplification region thought to contain an oncogene or dominant-immortalizing gene. BORIS is a candidate protein for the epigenetic reprogramming factor acting in the male germ line. BORIS is found in both the nucleus and cytoplasm. | | | Catalog # | B2560-35 | | Cellular Localization | Nuclear and cytoplasmic | | Positive Control | Human prostate. Also found in cancerous cell lines. | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: Detects a band of ~ 75kD. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | 0.02M Potassium phosphate, 0.15 M Sodium chloride pH7.2 | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide (Human) - amino acids 9-26 of human BORIS. | | Specificity | Species Crossreactivity: Crossreacts with Human. Expected to cross react with chimpanzee. May react with mouse, canine and rat sources based on sequence homology. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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