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You are here:Home » Antibodies » Abs to Binding Proteins » Anti -BORIS (Brother of the Regulator of Imprinted Sites)

Anti -BORIS (Brother of the Regulator of Imprinted Sites)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
BORIS (Brother of the Regulator of Imprinted Sites) also known as CCTC-binding factor-like protein, is normally only expressed in the testis and expressed in a mutually exclusive manner with CTCF during male germ cell development. However, previous studies have shown that BORIS is abnormally activated in a wide range of human cancers. Expression of BORIS in normally BORIS-negative cells promotes cell growth that may lead to transformation. BORIS maps to the cancer-associated amplification region thought to contain an oncogene or dominant-immortalizing gene. BORIS is a candidate protein for the epigenetic reprogramming factor acting in the male germ line. BORIS is found in both the nucleus and cytoplasm.
Catalog #B2560-35
Cellular Localization Nuclear and cytoplasmic
Positive Control Human prostate. Also found in cancerous cell lines.
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: Detects a band of ~ 75kD.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
Form0.02M Potassium phosphate, 0.15 M Sodium chloride pH7.2
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide (Human) - amino acids 9-26 of human BORIS.
SpecificitySpecies Crossreactivity: Crossreacts with Human. Expected to cross react with chimpanzee. May react with mouse, canine and rat sources based on sequence homology.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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