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Bortezomib, Free Base (Velcade, MG-341, PS-341, [(1S)-3-methyl-1-[[(2R)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic Acid)
Bortezomib, Free Base (Velcade, MG-341, PS-341,
[(1S)-3-methyl-1-[[(2R)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic
Acid)
Pricing
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| Bortezomib is the active ingredient in the drug sold under the trade name Velcade®. This drug has been approved in at least one country to treat multiple myeloma. It is a potent (Ki, 0.6nM), specific and reversible proteasome inhibitor. There is not any significant inhibitory activity against other enzymes or receptors. In a study with the National Cancer Institute's panel of 60 human cell lines, Bortezomib showed a mean IC50 of 7nM as tested by SRB analysis. | | | Bortezomib is active in preclinical models of human prostate cancer, while its effects on apoptosis versus angiogenesis are cell type dependent. Bortezomib caused comparable growth suppression in LNCaP-Pro5 and PC3M-Pro4 cells with an IC90 of 10nM. Bortezomib inhibits cell proliferation of H460 cells (Human non-small cell lung cancer cell lines) with an IC50 of 0.1uM. | | | Catalog # | B2572-02 | | Solubility | Soluble in DMSO at 200mg/ml. Soluble in ethanol at 200mg/ml. Very poorly soluble in water. Maximum solubility in plain water is estimated to be about 5-10uM. | | Melting Point | As reported | | Storage and Stability | May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. | | CAS Number | 179324-69-7 | | Molecular Formula | C19H25BN4O4 | | Molecular Weight | 384.24 | | Purity | HPLC | | Form | Supplied as a white to off-white powder | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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