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You are here:Home » Growth Factors, Cytokines » Growth Factors-BDNF » Brain-Derived Neurotrophic Factor, Recombinant, Human (BDNF)

Brain-Derived Neurotrophic Factor, Recombinant, Human (BDNF)

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Specifications

BDNF (brain-derived neurotrophic factor) is a potent neurotrophin and member of the NGF-beta family, secreted from dense core vesicles, which promotes the growth, differentiation and survival of neurons within, or directly connected to, the central nervous system (CNS). BDNF signals through binding to the high affinity receptor trkB, and also binds to the low affinity neurotrophin receptor LNGFR. Studies have shown the involvement of BDNF in the modulation of short-term synaptic function and in the formation of long-term memory, and reduced levels of BDNF are seen in patients with Alzheimer's and Huntington disease.
Catalog #B2700-01G
SourceE. coli
ApplicationsSuitable for use in Functional Assays. Other applications not tested.
Biological ActivityED50 for this effect is 0.5-1.0ug/ml.
Endotoxin 1EU/ug
Molecular Weight 27kD
Storage and StabilityLyophilized powder may be stored at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity98% (SDS PAGE and HPLC)
Concentration~0.1mg/ml
FormSupplied as a lyophilized powder. Reconstitute in 100ul distilled water.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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