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You are here:Home » Antibodies » Antibodies-Growth Factors, Cytokines » Anti -Brain Derived Neurotrophic Factor (BDNF)

Anti -Brain Derived Neurotrophic Factor (BDNF)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer?s, and Parkinson?s disease. ; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
Catalog #B2700-02E
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable at -20°C for 12 months upon receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
Concentration~1mg/ml (after reconstitution)
FormSupplied as a lyophilized powder. Reconstitute with 500ul sterile dH2O. Centrifuge to remove any insoluble material.
PurityPurified by Protein G affinity chromatography.
ImmunogenA synthetic peptide corresponding to aa129-138, HSDPARRGEL of huaman BDNF protein conjugated to KLH. Cellular Localization:
Secreted protein. POst translation modificationConverted into mature BDNF by plasmin (PLG). Belongs to the NGF-beta family.
SpecificityRecognizes human BSNF. Species Crossreactivity: mouse, rat.
0.1% cross reactivity with mouse NGF, recombinant human NT3 and NT4/5 has been recorded by dot blot analysis.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAbrineurin

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