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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -Brain Derived Neurotrophic Factor (BDNF)

Anti -Brain Derived Neurotrophic Factor (BDNF)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer?s, and Parkinson?s disease. ; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
Catalog #B2700-02J
Cellular LocalizationSecreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG). Belongs to the NGF-beta family.
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Reconstitute to nominal volume by adding sterile 40-50% glycerol, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceMouse
Concentration~1mg/ml
FormSupplied as a lyophilized powder. Reconstitute in 50ul of sterile water. Centrifuge to remove any insoluble material.
PurityPurified by affinity chromatography.
ImmunogenA synthetic peptide (HSDPARRGEL) as a part of mouse BDNF protein (aa: 131-140) conjugated to KLH.
SpecificityLess than 0.1% cross reactivity with mouse NGF, recombinant human NT3 and NT4/5 has been recorded by dot blot analysis. This antiserum also easily recognizes recombinant human BDNF in western blot. Species Crossreactivity: This antiserum is known to recognize rat and human BDNF.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAbrineurin


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