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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -Brain Derived Neurotrophic Factor (BDNF)

Anti -Brain Derived Neurotrophic Factor (BDNF)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimerís, and Parkinsonís disease. Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
Catalog #B2700-02P
ApplicationsSuitable for use in ELISA, Western Blot, Inhibition and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: 1-10ug/ml
Western Blot, Dot Blot: 1-10ug/ml
ELISA: 0.1ug/ml
Inhibition: 1-10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a lyophilized powder. Reconstitute in 500ul of sterile ddH2O. Centrifuge to remove any insoluble material.
PurityPurified by affinity chromatography.
ImmunogenRecombinant human BDNF.
SpecificityRecognizes human Brain Derived Neurotrophic Factor. <0.1% crossreactivity against NGF, recombinant NT3 and NT4 by Dot Blot. Species Crossreactivity: rat and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAbrineurin


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