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You are here:Home » Molecular Biology » MB-Peptides » Brain Natriuretic Peptide, Pro, NT, aa1-76, Recombinant, Human (NT-proBNP, N-terminal prohormone brain natriuretic peptide)

Brain Natriuretic Peptide, Pro, NT, aa1-76, Recombinant, Human (NT-proBNP, N-terminal
prohormone brain natriuretic peptide)

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Specifications

In cardiac tissue brain natriuretic peptide (BNP) is synthesized as 134aa precursor (prepro-BNP), which is cleaved by proteases to form a 26aa "signal" peptide and a 108aa pro-BNP. Proteolytic digestion of pro-BNP results in formation of 76aa amino-terminal NT-proBNP and biologically active 32aa BNP hormone molecule. Both proBNP and NTproBNP circulate in human plasma and have been proposed as markers for early diagnosis of left ventricular dysfunction as well as prognostic markers of possible cardiac complications at patients with heart failure.
Catalog #B2702-03F
Immunoreactivity is confirmed by reaction with monoclonal antibodies against different epitopes of NT-proBNP.
SourceRecombinant human pro-Brain Natriuretic peptide, NT, expressed in E. coli.
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityAliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months.
SourceE. coli
Purity95% pure (Tricine-SDS-PAGE, reducing conditions).
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4. No preservatives added.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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