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You are here:Home » Antibodies » Abs to Peptides » Anti -Brain Natriuretic Peptide (BNP)

Anti -Brain Natriuretic Peptide (BNP)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Brain natriuretic peptide (BNP) circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. BNP is secreted predominantly by the left ventricular myocytes in response to volume expansion and pressure overload. BNP belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C-type natriuretic peptide (CNP) and urodilatin. These peptides are characterized by a common 17 amino acid ring structure with a disulfide bond between two cystein residues. This ring structure shows high homology between different natriuretic peptides (eleven of the 17 amino acid residues are homologous in the ring of each of the natriuretic peptides, see fig. 18). BNP is a 32 amino acid peptide with disulfide bond between the cystein residues Cys10 and Cys26. In earlier studies it has been demonstrated that BNP concentration in blood increases with the severity of congestive heart failure. Quantitative measurement of BNP in blood provides an objective indicator of congestive heart failure severity
Catalog #B2702-31
Cellular Localization Secreted
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8J370
HostMouse
SourceHuman
Concentration~2mg/ml
FormSupplied as a liquid in PBS, pH 7.4, containing 0.1% sodium azide.
PurityPurified by Protein A affinity chromatography.
Immunogen32 amino acid synthetic peptide corresponding to a.a. 77-108 of proBNP molecule, conjugated with carrier protein
SpecificityRecognizes human BNP and proBNP
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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