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You are here:Home » Antibodies » Antibodies-Neuroscience » Anti -Brain-Specific Angiogenesis Inhibitor 3 (BAI3)

Anti -Brain-Specific Angiogenesis Inhibitor 3 (BAI3)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Human BAI-3 (brain-specific angiogenesis inhibitor 3) is a 177kD, 7-transmembrane (TM) member of the secretin receptor family. It is synthesized by neurons of the CNS and likely is a negative regulator of angiogenesis. BAI-3 is 1498 amino acids (aa) in size. It contains three distinct regions; an N-terminal extracellular domain (ECD) (aa 25-883), a 7-TM segment, and a C-terminal cytoplasmic region. The ECD contains four antiangiogenic TSP type1 repeats (aa 296-508), and one GPS domain (aa 816-867) that is likely used to cleave the ECD from the membrane-bound receptor. There is one alternate splice form that shows a deletion of aa 643-665. Over aa 25-880, human BAI-3 is 98% aa identical to mouse BAI-3.
Catalog #B2704-12A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionDirect ELISA: 0.5-1ug/ml. The detection limit is ~3ng/well.
Western Blot: 1-2ug/ml. Using a colorimetric system, the detection limit is ~5ng/lane under non-reducing conditions.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute by adding sterile 40-50% glycerol, PBS. Reconstituted product is stable for 12 months at -20ºC. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No7H218
FormSupplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile 40-50% glycerol., PBS
PurityPurified by Protein G affinity chromatography.
ImmunogenNS0-derived recombinant human BAI-3 (aa25-880) Accession #O60242
SpecificityRecognizes human BAI-3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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