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You are here:Home » Antibodies » Abs to Neuroscience » Anti -Brain-Specific Receptor-like Protein A (BSRP-A)

Anti -Brain-Specific Receptor-like Protein A (BSRP-A)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified E B IH
BSRP-A (Brain-specific receptor-like protein A; also SEZ6L2) is a 170kD member of the BSRP family of proteins. It is expressed in the plasma membrane and ER of CNS neurons, and likely regulates PKC alpha activation. Mature mouse BSRP-A is an 890aa type I transmembrane protein. It contains an 824aa extracellular domain (ECD) (aa21-844) and a 43aa cytoplasmic tail. The ECD shows two CUB domains and five short consensus repeats (SCRs). There are multiple isoforms for BSRP-A. One shows a premature truncation after Arg403, a second shows a deletion of aa71-130, and a third likely represents the full-length form that contains a 13aa
insertion after Val830. Over aa28-837, mouse BSRP-A is 96% and 99% aa identical to human and rat BSRP-A, respectively.
Applications:
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Catalog #B2704-25
Recommended DilutionELISA (Direct): 0.5-1ug/ml Detection limit for recombinant mouse BSRP-A is ~1ng/well.
Western Blot: 2ug/ml cell or tissue extracts
Immunohistochemistry: 25ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No9H71
HostRat
SourceMouse
Concentration~500ug/ml
FormSupplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant protein corresponding to aa28-837 from mouse BSRP-A, expressed in NSO cells (Accession# Q4V9Z5). Species Sequence Homology: human 96%, rat 99%.
SpecificityRecognizes mouse BSRP-A. Does not recognize recombinant mouse BSRP-B or recombinant mouse BSRP-C in direct ELISA.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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