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You are here:Home » Antibodies » Antibodies-Transcription Factors, Zinc (Ring) Finger » Anti -BRCA1 (Breast Cancer Type 1 Susceptibility Protein, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PSCP, RING Finger Protein 53, RNF53)

Anti -BRCA1 (Breast Cancer Type 1 Susceptibility Protein, BRCAI, BRCC1, BROVCA1, IRIS,
PNCA4, PSCP, RING Finger Protein 53, RNF53)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
The breast cancer tumor-suppressor gene, BRCA1, encodes a protein with a BRCT domain, a motif that is found in many proteins that are implicated in DNA damage response and in genome stability. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. BRCA1 functions in the nuclear processes of transcription, chromatin remodeling and silencing, and in various DNA repair mechanisms. It also has ubiquitin ligase activity. It regulates key effectors that control the G2/M checkpoint and is therefore involved in regulating the onset of mitosis. It is a protein of unknown structure and has a few identifiable features. The C-terminus of BRCA1 contains two 95-residue BRCT domains. Pathological role of the protein has been identified in breast and ovarian cancer. Many alternatively spliced transcript variants have been described for this gene with only some have had their full-length natures identified
Catalog #B2709-01P
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlHT-29 and K562 cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to human BRCA1 around the phosphorylation site of serine 1423 (H-G-SP-Q-P).
SpecificityRecognizes human BRCA1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesBreast Cancer 1, Early Onset, EC=6.3.2.-

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