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Abs to Transcription Factors, Zinc (Ring) Finger
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Anti -BRCA1 (Breast Cancer Type 1 Susceptibility Protein, RING Finger Protein 53, RNF53)
Anti -BRCA1 (Breast Cancer Type 1 Susceptibility Protein, RING Finger Protein 53, RNF53)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IP IH |
|
| BRCA1 is a breast cancer susceptibility gene that was localized to chromosome 17q. Mutations within this gene are believed to account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863aa. Like many other genes involved in familial cancer, BRCA1 appears to encode a tumor suppressor, a protein that acts as a negative regulator of tumor growth. | | | Catalog # | B2709-05S | | Applications | Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1-4ug/ml | | Immunoprecipitation: 10-20ug/ml | | Immunohistochemistry: 10-20ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | LgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol. | | Purity | Purified by affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa1852 from human BRCA1. | | Specificity | Recognizes human BRCA1. Species Crossreactivity: mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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