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You are here:Home » Antibodies » Abs to Transcription Factors, Zinc (Ring) Finger » Anti -BRCA1, Phosphorylated (Ser1189) (Breast Cancer Type 1 Susceptibility Protein, RING Finger Protein 53, RNF53)

Anti -BRCA1, Phosphorylated (Ser1189) (Breast Cancer Type 1 Susceptibility Protein, RING
Finger Protein 53, RNF53)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
BRCA1 is a breast cancer susceptibility gene that was localized to chromosome 17q. Mutations within this gene are believed to account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863aa. Like many other genes involved in familial cancer, BRCA1 appears to encode a tumor suppressor, a protein that acts as a negative regulator of tumor growth.
Catalog #B2709-05T
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 1% BSA, 0.02% thimerosal, 50% glycerol.
PurityPurified by affinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to Serine 1189 from human BRCA1.
SpecificityRecognizes human BRCA1 when phosphorylated at Ser1189.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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