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You are here:Home » Antibodies » Abs to Disease Markers » Anti -BRCC36, NT (Lys-63-specific Deubiquitinase BRCC36, BRCA1-A Complex Subunit BRCC36, BRCA1/BRCA2-containing Complex Subunit 3, BRCA1/BRCA2-containing Complex Subunit 36, BRISC Complex Subunit BRCC36, BRCC3, C6.1A, CXorf53)

Anti -BRCC36, NT (Lys-63-specific Deubiquitinase BRCC36, BRCA1-A Complex Subunit BRCC36,
BRCA1/BRCA2-containing Complex Subunit 3, BRCA1/BRCA2-containing Complex Subunit 36, BRISC
Complex Subunit BRCC36, BRCC3, C6.1A, CXorf53)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
BRCC-36 is a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. It is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains, and does not have activity toward 'Lys-48'-linked polyubiquitin chains. In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint.
Catalog #B2727-01A
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 18aa from human BRCC36 at N-terminal (KLH).
SpecificityRecognizes human BRCC36. Species sequence homology: Mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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