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Anti -BRCC36 (Lys-63-specific Deubiquitinase BRCC36, BRCA1-A Complex Subunit BRCC36, BRCA1/BRCA2-containing Complex Subunit 3, BRCA1/BRCA2-containing Complex Subunit 36, BRISC Complex Subunit BRCC36, BRCC3, C6.1A, CXorf53)
Anti -BRCC36 (Lys-63-specific Deubiquitinase BRCC36, BRCA1-A Complex Subunit BRCC36,
BRCA1/BRCA2-containing Complex Subunit 3, BRCA1/BRCA2-containing Complex Subunit 36, BRISC
Complex Subunit BRCC36, BRCC3, C6.1A, CXorf53)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IH |
|
| BRCC-36 is a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. It is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains, and does not have activity toward 'Lys-48'-linked polyubiquitin chains. In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint. | | | Catalog # | B2727-01E | | Applications | Suitable for use in Western Blot, ELISA and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000-1:2000 | | Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1,k | | Clone No | AT3B1 | | Host | Mouse | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Recombinant corresponding to 1-316aa of human BRCC3, expressed in E.coli. | | Specificity | Recognizes human BRCC3. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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