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Anti -Breast Cancer Resistance Protein (BCRP)
Anti -Breast Cancer Resistance Protein (BCRP)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Supernatant |
IH IC FC |
|
| Breast Cancer Resistance Protein (BCRP) is a 70kD ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone. | | | Catalog # | B2738-01A | | Applications | | | Suitable for use in Flow Cytometry, Immunocytochemistry and Immunohistochemistry. Not recommended for Western Blot. Other applications have not been tested. | | Recommended Dilution | Immunocytochemistry: 1:20-1:50 using acetone-fixed cytospin preparations. | | Immunohistochemistry (frozen sections): 1:20 dilution using acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex. Not suitable for use on formaldehyde-fixed paraffin-embedded human tissues and tumors. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 6D169 | | Host | Mouse | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid, 0.7% BSA, % sodium azide. | | Purity | Supernatant | | Immunogen | Mitoxanthone resistant BCRP (breast cancer resistance protein; MXR) overexpressing cell line MCF7MR. | | Specificity | Recognizes an internal epitope of human BCRP. Does not cross-react with human P-glycoprotein, MRP1, MRP2 or MRP5. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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